The pair are believed to have put up a number of their joint properties for sale.
The pair purchased the property in 2007 after Hurricane Katrina when the Hollywood actor established the Make It Right Foundation in the city.
Documents obtained by The Hollywood Reporter show that the five-bedroom, three-bathroom home was sold for $4.9 million.
“It sold for a very fair price. It’s a good deal for both parties. They’re happy with the outcome,” listing agent Nina Killeen confirmed.
The couple’s $60m Château Miraval, in France, where they produce wine was also recently put up for sale.